Polymyxins: Antibacterial activity, resistance mechanisms and epidemiology of plasmid mediated resistance
نویسندگان
چکیده
منابع مشابه
[Mechanisms of plasmid-mediated resistance to quinolones].
Quinolone resistance is caused mainly by chromosomal mutations in gram negative bacteria. In 1998, plasmid-mediated resistance to quinolones in clinical isolates was first reported in a Klebsiella pneumoniae strain. Locus qnr (quinolone resistance) was responsible of the quinolone resistance in this plasmid. qnr codes a protein whose function is protect both DNA-girase and topoisomerase IV from...
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Multidrug resistance in pathogens is an increasingly significant threat for human health. Indeed, some strains are resistant to almost all currently available antibiotics, leaving very limited choices for antimicrobial clinical therapy. In many such cases, polymyxins are the last option available, although their use increases the risk of developing resistant strains. This review mainly aims to ...
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ژورنال
عنوان ژورنال: Medicinski podmladak
سال: 2019
ISSN: 0369-1527,2466-5525
DOI: 10.5937/mp70-19934